Cellwright Bio
From tissue to molecule.
We design medicines at the scale where disease actually begins. Scroll down through six orders of magnitude, from a field of cells to a single gene.
Scroll to zoom in
01 / 05 · 100 µm
Disease starts small.
Long before symptoms, something changes in a tissue: a few cells behaving differently from their neighbours.
Fluorescence imaging: membranes in green, nuclei in blue.
02 / 05 · 10 µm
Inside one cell.
Mitochondria power it, vesicles move cargo, and at the centre the nucleus holds the instructions for all of it.
A typical human cell is about 10 micrometres across.
03 / 05 · 1 µm
The genome, unwound.
Two metres of DNA packed into a nucleus a hundred times narrower than a hair, folded so the right genes stay within reach.
Chromatin: DNA wrapped around proteins, coiled and looped.
04 / 05 · 2 nm
Reading the code.
Down at the double helix, every disease variant is a precise address: a handful of letters in three billion.
The helix is 2 nanometres wide and turns once every 10.5 base pairs.
05 / 05 · 0.3 nm
One target. One molecule.
We design compounds that find that address and bind it, and nothing else. This is where a medicine begins.
Designed against structure, validated in patient-derived cells.
Precision starts with seeing clearly.
Platform
Our platform pairs single-cell imaging with structural modelling, so every candidate is designed against the exact sequence it needs to reach, in the cells where it matters.
CW-101 · Discovery
Rare metabolic disease
Small molecules that restore a single misfolded enzyme in liver cells.
CW-204 · Lead optimisation
Inherited retinal disease
Sequence-targeted therapy for one of the most common causative variants.
CW-310 · Preclinical
Neuromuscular disorders
Splice-modulating compounds designed against patient-derived cells.
10⁶×
Range of scales we model
3
Programs in development
40M
Single cells imaged
1
Base pair at a time